VTE is a leading cause
of Death and Disability Worldwide.

Yet, no one talks about it.

VTE is a silent killer.

For 1 in 4 patients, a fatal PE is the first symptom of VTE

Blood Clots are Deadly and
a Significant, Growing Public Health Problem

Affected by Blood Clots
Blod Clot Related Deaths
= 100, 000

Blood Clots affect as many as

900,000 Americans

each year leading to approximately

100,000 premature deaths





50%

of blood clots are healthcare associated

Although there are many reasons a person might develop a blood clot, about half of them are directly related to a recent hospitalization or surgery and most of these do not occur until after discharge

UP TO

80%

of fatal VTE events occur in
acutely ill medical patients
Huang et al, 2015

 

1 in 4

people worldwide die of
VTE-related conditions
World Thrombosis Day

In the US, VTE is deadlier than colon cancer,
diabetes, flu, and pneumonia

VTE causes ~100,000 confirmed annual deaths in the United States alone

52K

COLON CANCER

55K

FLU/ PNEMONIA

76K

DIABETES

100K

TOTAL VTE (DVT/PE)

The unmet medical need

There is a need for extended-duration VTE prophylaxis that provides…

VTE risk reduction during the highest risk period

Significant risk reduction versus standard of care

References

  • 1. Futterman LG, Lemberg L. A silent killer—often preventable. Am J Crit Care. 2004;13(5):431-436.
  • 2. Office of the Surgeon General and National Heart, Lung, and Blood Institute (US). The Surgeon General's Call to Action to Prevent Deep Vein Thrombosis and Pulmonary Embolism. Rockville, MD: Office of the Surgeon General (US); 2008.
  • 3. Beckman MG, Hooper WC, Critchley SE, Ortel TL. Venous thromboembolism: a public health concern. Am J Prev Med. 2010;38(4S):S495-S501.
  • 4. Korjian S, Daaboul Y, Halaby R, et al. Extended-duration thromboprophylaxis among acute medically ill patients: an unmet need. J Cardiovasc Pharmacol Ther. 2016;21(3):227-232.
  • 5. Roger VL, Go AS, Lloyd-Jones DM, et al; the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics—2011 update. Circulation. 2011;123(4);e18-e209.
  • 6. Ng TMH, Tsai F, Khatri N, Barakat MN, Elkayam U. Venous thromboembolism in hospitalized patients with heart failure: incidence, prognosis, and prevention. Circ Heart Fail. 2010;3(1):165-173.
  • 7. Kelly J, Rudd A, Lewis R, Hunt BJ. Venous thromboembolism after acute stroke. Stroke. 2001;32(1):262-267.
  • 8. Tapson VF. The role of smoking in coagulation and thromboembolism in chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2005;2(1):71-77.